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Genes and Common Diseases(ISBN=9780521541008)书籍详细信息
- ISBN：9780521541008
- 作者：暂无作者
- 出版社：暂无出版社
- 出版时间：2007-08
- 页数：544
- 价格：699.80
- 纸张：胶版纸
- 装帧：平装
- 开本：32开
- 语言：未知
- 丛书：暂无丛书
- TAG：暂无
- 豆瓣评分：暂无豆瓣评分
内容简介：
Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.
书籍目录：
1 Genes and their expression
? Dirk-Jan Kleinjan
2 Epigenetic modification of chromatin
? Donncha Dunican, Sari Pennings and Richard Meehan
3 Population genetics and disease
? Donald F. Conrad and Jonathan K. Pritchard
4 Mapping common disease genes
? Naomi R. Wray and Peter M. Visscher
5 Population diversity, genomes and disease
? Gianpiero L. Cavalleri and David B. Goldstein
6 Study design in mapping complex disease traits
? Harry Campbell and Igor Rudan
7 Diseases of protein misfolding
? Christopher M. Dobson
8 Aging and disease
? Thomas T. Perls
9 The MHC paradigm: genetic variation and complex
disease
? Adrian P. Kelly and John Trowsdale
10?Lessons from single gene disorders
? Nicholas D. Hastie
11?Environment and disease
? A.?J. McMichael and K.?B.?G. Dear
12?Contemporary ethico-legal issues in genetics
? Renate Gertz, Shawn Harmon and Geoffrey Pradella
Section 2: Common Medical Disorders
13?Developmental disorders
? Stephen P. Robertson and Andrew O.?M. Wilkie
14?Genes, environment and cancer
? D. Timothy Bishop
15?The polygenic basis of breast cancer
? Paul D.?P. Pharoah and Bruce A.?J. Ponder
16?TP53: A master gene in normal and tumor suppression
? Pierre Hainaut
17?Genetics of colorectal cancer
? Susan M. Farrington and Malcolm G. Dunlop
18?Genetics of autoimmune disease
? John I. Bell and Lars Fugger
19?Susceptibility to infectious diseases
? Andrew J. Walley and Adrian V.?S. Hill
20?Inflammatory bowel diseases
? Jean-Pierre Hugot
21?Genetic anemias
? W.?G. Wood and D.?R. Higgs
22?Genetics of chronic disease: obesity
? I. Sadaf Farooqi and Stephen O'Rahilly
23?Type 2 diabetes mellitus
? Mark I. McCarthy
24?Genetics of coronary heart disease
? Rossi Naoumova, Stuart A. Cook, Paul Cook and Timothy J.
Aitman
25?Genetics of hypertension
? B. Keavney and M. Lathrop
26?Obstructive pulmonary disease
? Bipen D. Patel and David A. Lomas
27?Skeletal disorders
? Robert A. Colbert
28?The genetics of common skin diseases
? Jonathan Rees
29?Molecular genetics of Alzheimer's disease and other adult-onset
dementias
? P.?H. St George-Hyslop
30?Major psychiatric disorders in adult life
? Amanda Elkin, Sridevi Kalidindi, Kopal Tandon and Peter
McGuffin
31?Speech and language disorders
? Gabrielle Barnby and Anthony J. Monaco
32?Common forms of visual handicap
? Alan Wright
33?Genetic and environmental influences on hearing
impairment
? Karen P. Steel
34?Pharmacogenomics: clinical applications
? Gillian Smith, Mark Chamberlain and C. Roland Wolf
Index
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编辑推荐
Genes and Common Diseases presents an up-to-date view of the
role of genetics in modern medicine, reflecting the strengths and
limitations of a genetic perspective. The current shift in emphasis
from the study of rare single gene disorders to common diseases
brings genetics into every aspect of modern medicine, from
infectious diseases to therapeutics. However, it is unclear whether
this increasingly genetic focus will prove useful in the face of
major environmental influences in many common diseases. The book
takes a hard and self-critical look at what can and cannot be
achieved using a genetic approach and what is known about genetic
and environmental mechanisms in a variety of common diseases. It
seeks to clarify the goals of human genetic research by providing
state-of-the art insights into known molecular mechanisms
underlying common disease processes while at the same time
providing a realistic overview of the expected genetic and
physiological complexity.
? Written by leading experts in genetics at a level that the
practising clinician can understand ? Introductory sections explain
the basics of genetics and molecular medicine, setting the scene
for the disease chapters in the following section ? Wide range of
clinical disorders covered and clear illustrations which help
explain complex genetic concepts
书籍介绍
Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.
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